Endocrine Abstracts

Background: Accurate early risk prediction for gestational diabetes mellitus (GDM) would target intervention and prevention in women at the highest risk. We evaluated maternal risk factors and parameters of body composition to develop a prediction model for GDM in early gestation.Methods: A prospective observational study was undertaken. Pregnant women aged between 18–50 y of age with gestational age between 10–16 weeks were included in ...

Background: Globally, birth-weights are increasing progressively. Birth-weights large for gestational age (LGA) defined as ≥90th centile are linked to increased delivery complications, and adiposity in the neonate. This has been linked to glucose intolerance and CVD later in life. Oversupply of nutrients in utero contribute to excess foetal growth, and maternal obesity may contribute to this rise. The aim of this study is to examine the relationship between para...

Background: Adipocytokines are biologically active substances produced by adipocyte with different physiological functions. Adiponectin, an adipocyte derived protein has multiple effects on homeostatic mechanism that regulate body weight and metabolism. Leptin, a signal of satiety to the brain, is considered as a proinflammatory adipocytokine. Thyroid hormones act on several aspects of metabolic and energy homeostasis influencing body weight, thermogenesis, and lipolysis in ad...

Objective: Impaired cognitive function has been demonstrated in adults with GH deficiency (GHD) by using different neuropsychological tests. P300 ERP application is a well established neurophysiological approach in the assessment of cognitive function. Kickboxing is a novel cause of hypopituiatarism due to sports related traumatic brain injury (TBI) and isolated GHD is the most common problem (1).The present preliminary study was therefore designed to in...

Introduction: Metabolic syndrome (MS) is a clustering of risk factors. Endothelial dysfunction has been reported in patients with MS and even in healthy obese individuals with a normal metabolic profile. Sympathetic activity commonly is increased in obese hypertensives, and moxonidine, is found to be effective in lowering blood pressure and improving insulin sensitivity. The aim of this study is to evaluate the efficacy of moxonidine on endothelial dysfunction in insulin-resis...

A 42 year old gentleman presented for a second opinion regarding management of Congenital Adrenal Hyperplasia (CAH) of the salt losing variety. The patient had been under long term follow up elsewhere but had discontinued his medication of his own accord 14 months prior to seeking consultation. Examination revealed a heavily pigmented male patient with protuberant belly. He had easily palpable masses in both flanks. An abdominal CT showed bilateral massive adrenal enlargement ...

An 18 year old young man was first seen in the ENT department with bilateral swelling of the supraclavicular fossae. A clinical diagnosis of Cushing's syndrome was made and the patient was referred to the Endocrine team. Examination showed a BP of 150/100 and clinical features of gross Cushing's syndrome. Initial investigations revealed normal electrolytes, fT4 8.7 pmol/L, TSH 0.69 mIU/L and a basal prolactin of 68280 mIU/ml. A 24 hr urinary free cortisol (UFC) was 3860 nmol/L...

Introduction: Although dipeptidyl peptidase-4 (DPP-4) inhibitores are generally safe and are associated with less side effects compared to other oral antidiabetic medications, they could also be associated with some side effects including skin rash. Herein we report the first case of a type 2 diabetes patient who developed a painfull maculopapular rash induced by linagliptin, a widely used DPP-4 inhibitor.Case presentation: A-54-year old female patient w...

Introduction: Obstructive sleep apnea syndrome (OSAS) is a common disorder whose prevalence is linked to an epidemic of obesity. OSAS is caused by recurrent episodes of upper airway obstruction during sleep, leading to reduction or cessation of the airflow. Studies have shown a strong association among OSAS and cardiovascular morbidity and mortality. Therefore, currently we performe overnight polysomnograpy in all patients with obesity in our outpatient clinic. In order to obs...

Introduction: Due to the risk of thyroid storm, achievement of euthyroid state is necessary in patients with thyrotoxicosis undergoing surgery. However, euthyroid state could not be always achieved by antithyroid drugs. Therefore, therapeutic plasmapheresis (TPE) can be used for this purpose.Case 1: A-58-year old male patient was admitted to emergency department with diabetic ketoacidosis (DKA) induced by amiodarone induced thyrotoxicosis (AIT). He had a...